High Blood Pressure and Intranasal Light Therapy

Introduction

High blood pressure (hypertension) is a common condition in which the long-term force of the blood against your artery walls is abnormally high enough that it may eventually cause health problems, such as heart disease. High blood pressure is associated with several cardiovascular diseases, a common bane of people over the age of 40.


Research Examples

In 2008, Mokmeli and her research team found that exposing the blood circulation system to low level laser energy (photobiomodulation) is effective at reducing high blood pressure. Their method of delivery utilized the intravascular blood irradiation method(invasive insertion of a needle laser diode into the blood vessels).[i]

View an extract of this study on the effect of intravascular laser therapy on hypertension.


In mid-2012, Professor Timon Liu published a landmark study on the effect of Intranasal Light Therapy on factors that affect high blood pressure.[i]

The research results in both studies were statistically promising.


An explanation

While the studies above were conducted using the intravenous blood irradiation method, intranasal light therapy achieves the same outcome by using a non-invasive method. View the research comparing intranasal versus intravenous light therapy.

There are several explanations about the mechanisms behind the reduction in high blood pressure. Firstly, the cellular processes triggered by molecular signalling through photonic irradiation provides a strong argument. View more details on biostimulation with intranasal light therapy.

Blood viscosity, erythrocyte aggregation index and erythrocyte deformabilities are factors associated with high blood pressure. These are further covered in our article on lowering blood pressure with intranasal light therapy.


In-depth explanation

Although high blood pressure could have various causes, persistent high viscosity and red blood cell aggregation are key risk factors. Intranasal light therapy is supported by studies to reduce the risk of these factors.

  • High blood pressure, high blood viscosity and red blood cell aggregation

The symptoms that are usually associated with high blood pressure are high blood and plasma viscosity and red blood cell aggregation. The compromised deformability of red blood cells is also a contributor to high blood pressure.[1]

As far back as 1930, Harris and McLoughlin measured the blood viscosity of two groups of men – normal versus high blood pressure and concluded that in many cases, blood viscosity was a contributing factor towards high blood pressure.[2]

Similar findings were reported in 1966 by Tibbin et al. reported that both blood and plasma viscosity were higher in hypertensive subjects than in normotensives.[3]

Dintenfass wrote, “But approaching this problem (high blood pressure) from the viewpoint of blood rheology, one cannot dismiss the possibility that the “unknown aetiology” might comprise, or be a result of, increased blood viscosity, increased rigidity of red cells, etc.”[4]

Letcher et al confirmed that blood viscosity was higher in hypertensives than in normotensives, and reported that this was due to higher levels of fibrinogen, which increased plasma viscosity.[5]

Subsequently, they reported that in borderline hypertension, increased blood viscosity was associated with higher hematocrits and plasma viscosity and greater red blood cell (RBC) aggregation.[6]

More recent studies by leading blood rheology researchers, such as Shu Chien, are consistent in their findings that blood rheology in the form of viscosity and RBC aggregation play a significant role in high blood pressure.[7]

Despite many published studies that have identified high blood pressure with high blood viscosity and red blood cell aggregation, there is currently no pharmaceutical that would result in the reduction of blood viscosity and red blood cell aggregation with no side effects.

Simpson argued that medical experts have been unwilling to accept this information or exhibit a lack of interest because of the premise that high blood pressure is a disease entity, although the various causes are not clearly identifiable on diagnoses and are attributable to natural factors such as aging.[8]

  • A narrow study on intravenous light therapy for hypertension

The procedure focused on reading the systolic blood pressure on 3 groups: normotensive (25 subjects with readings of less than 120 mmHg), pre-hypertensive (50 subjects with readings of 120-139 mmHg) and hypertensive stage 1 (50 subjects with readings of 140-159 mmHg).

All groups were treated for 30 minutes with the intravenous irradiation method described above by employing a 630 nm low level laser beam continuously powered with 2.5 mW of energy at the end of the intravenous fibre. Pulse rate, systolic, diastolic, and pulse pressures were measured before and 15 minutes after each treatment.[9]

The results were as follows:  There was no statistical difference for the pulse rate, systolic rate, and diastolic blood pressure in the normotensive group. However, there was significant difference in the readings for the pulse rate, systolic and diastolic blood pressure in the pre-hypertensive group as well as for the hypertensive  group.

In conclusion, the intravenous low level laser irradiation (photobiomodulation) method as described above is effective in reducing arterial blood pressure. The authors suggested that it can be combined with anti-hypertensive drugs in pre-hypertensive and hypertensive patients as a modality of treatment. It is also a safe method for normotensive patients even though it appears not to improve the blood pressure readings.


Intranasal low level light therapy (photobiomodulation) and high blood pressure

Intranasal light therapy and intravenous light therapy are based on the same principle – irradiation of the blood stream with low level light or laser of similar wavelength and dosage management.

The major difference is that the intranasal method fully leverages cutting edge semi-conductor technology to greatly miniaturize the needed equipment and the power, delivering the ease of use and improvement in comfort user experience.

Photobiology researchers concluded little difference between laser and light, notably Kendric Smith of Stanford University. [11] After reconciling the energy dosage, the main difference is in the power consumption.

Learn why intranasal light therapy is similar to intravenous light therapy here – Link

 

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Intranasal light therapy device in use

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Intranasal light therapy device

 

Why our intranasal technology works

As discussed above, a common factor among high blood pressure patients is high blood viscosity[12] and high erythrocyte aggregation[13].

In a randomized, double-blind, placebo-controlled study, Timon CY Liu et demonstrated with statistical significance that intranasal LLLT reduces blood and plasma viscosity, and red blood cell aggregation.[14]

This provides convincing data that intranasal light therapy plays a significant role in reducing high blood pressure for most patients since blood viscosity and aggregation are key factors behind high blood pressure.

Furthermore, vascular walls also dilate (vasodilatation) to allow blood with these problems to maintain its rheological properties, addressing a common problem of aging.

The figure below demonstrates the impact that our irradiation therapy has on erythrocyte aggregation.

 

Before          |           After

Before and after pictures of aggregated red blood cell subjected to low level light therapy blood irradiation treatment.

 

As we can see, it is apparent that erythrocyte aggregation is reversed after the blood stream is energized with red light, supported by the measurement in Timon Liu et al’s randomized, double-blind study mentioned above.


Other studies

Other studies are not directly relevant but provide additional data supporting photobiomodulation has the effect of lowering high blood pressure. One study reports that light therapy treatment on 42 men significantly lowered systolic, diastolic and mean arterial pressure. Total peripheral vascular resistance also decreased. A good hypotensive effect was achieved in 90.4% of the cases.[15] In another study, the effects of a low level laser on the control of blood pressure were tested via energy administered via the medulla oblongata. The results from a group of 30 patients suffering from hypertension were positive in 80% of the patients.[16]


Conclusion

In conclusion, credible scientific bases and evidence support LLLT and red LED irradiation of the blood for lowering high blood pressure. We can achieve this with the traditional intravenous irradiation of the blood or through a more convenient modern method by illuminating the nasal cavity – the results are the same.


References


[1] Simpson L. Blood viscosity factors: The missing dimension of modern medicine. Mumford Institute. 199-120.

[2] Harris I, McLoughlin G. The viscosity of blood in high blood pressure. Quart J Med 1930; 23:451-64.

 [3] Tibblin G, Bergentz S-E, Bjure J, et al. Haematocrit, plasma protein, plasma volume, and viscosity in early hypertensive disease. Am Heart J 1966; 72:72:165-72.

 [4] Dintenfass L. Rheology of blood in diagnostic and preventive medicine. Butterworth and Co., London, 1976: pp 102-103.

 [5] Letcher RL, Chien S, Pickering TG, et al. Elevated blood viscosity in patients with borderline hypertension. Hypertension 1983; 5:757-62.

 [6] Letcher RL, Chien S, Pickering TG et al. Elevated blood viscosity in patients with borderline hypertension. Hyertension 1983;5:757-62.

 [7] Chien S. Blood rheology in myocardial infarction and hypertension. Biorheology 1986;23:633-53.

 [8] Simpson L, Blood viscosity factors: The missing dimension of modern medicine. Mumford Institute: pp 201-203.

 [9] Mokmeli S, Bishe SH, Kohe KH, Shakhes M. Intravascular laser therapy (IVL) in pre-hypertension and hypertension conditions. Paper presented at The World Association of Laser Therapy (WALT) conference. 2008.

 [10] Mokmeli S, Bishe SH, Kohe KH, Shakhes M. Intravascular laser therapy (IVL) in pre-hypertension and hypertension conditions. Paper presented at The World Association of Laser Therapy (WALT) conference. 2008.

 [11] Smith KS. Laser and LED Biology. Laser Therapy 2010; 19:2: 72-78.

 [12] Ciufetti G, Schillaci G, Lombardini R, Pirro M, Vaudo G, Mannarino E. Plasma viscosity in isolated  systolic hypertension: the role of pulse pressure. American Journal of Hypertension 2005; 18:17: 1005-1008.

 [13] Lominadze D, Joshua IG, Schuschke DA. Increased erythrocyte aggregation in spontaneiously hypertensive rats. American Journal of Hypertension 1998; 11: pp 784-789.

 [14] Liu TCY, Cheng L, Su WJ, Zhang YW, Shi Y, Liu AH, Zhang LL, Qian ZY. Randomized, Double-Blind, and Placebo-Controlled Clinic Report of Intranasal Low-Intensity Laser Therapy on Vascular Diseases. International Journal of Photoenergy. 2012; ID 489713.

 [15] Velizhanina IA, Gapon LI, Shabalina MS et al. Efficiency of low intensity radiation in essential hypertension, Klinicheskaia Meditsina (Mosk), 2001; 79:1: 41-44.

 [16] A study cited by several websites referring to a study by Umeda, published in Laser Therapy, 1990; 2:2:59.